Joan M. Bathon, M.D.,
Medical Editor
Professor of Medicine,
Division of Rheumatology,
Johns Hopkins School of Medicine
Director, Johns Hopkins
Arthritis Center

Susan Bartlett, Ph.D.,
Assistant Professor of Medicine,
Division of Rheumatology,
Johns Hopkins School of Medicine

Clifton O. Bingham III, M.D.,
Assistant Professor of Medicine,
Division of Rheumatology,
Johns Hopkins School of Medicine

John Flynn, M.D.,
Associate Professor of Medicine,
Clinical Director,
Division of General Internal Medicine
Johns Hopkins School of Medicine

Kevin Fontaine, Ph.D,
Assistant Professor of Medicine,
Division of Rheumatology,
Johns Hopkins School of Medicine

Jon Giles, M.D.,
Instructor in Medicine,
Division of Rheumatology,
Johns Hopkins School of Medicine

Uzma Haque, M.D.,
Assistant Professor of Medicine,
Division of Rheumatology,
Johns Hopkins School of Medicine

The Johns Hopkins Arthritis Bulletin is a major new resource for comprehensive, up-to-the-minute coverage of essential medical news for arthritis sufferers.

• Quarterly briefings on the latest medical developments delivered via Priority Mail.

• Late-breaking news of innovative new treatments and health-essential study results.

• Expert evaluations and comparisons of new medications and diagnostic procedures.

• Authoritative medical guidance for coping with every form of arthritis.

If you or someone you love is facing any one of these health challenges, get the expert medical guidance you need in The Johns Hopkins Arthritis Bulletin:

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Arthritis can be one of the most debilitating health challenges you’ll ever experience. Don’t face it alone. Get the up-to-the-minute information you need to help ensure the optimal medical outcome for yourself or a loved one. Four times a year, the Johns Hopkins Arthritis Bulletin will deliver:

• News of breakthrough discoveries in arthritis medicine, diagnostics, treatment, and prevention.

• Health-critical research findings presented in plain jargon-free language.

• Insights from the top arthritis medical conferences around the world.

• Authoritative medical guidance from Johns Hopkins experts.

• Urgent health alerts about drug interactions, side effects, and contraindications.

• Answers to your questions about therapy, medication, pain relief, surgical options, and much more.

Every quarterly issue of The Johns Hopkins Arthritis Bulletin will include:

The Doctor's Letter
... covering the latest developments in arthritis medicine, surgical procedures, drug research, physical therapy, dietary discoveries, and more.

In-Depth Reports
... detailed discussions of key arthritis concerns such as joint replacement, minimally invasive surgical techniques, medication options, and more.

Grand Rounds
... your opportunity to present your own personal arthritis questions--and get clear, detailed answers from Johns Hopkins experts.

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The Johns Hopkins Arthritis Bulletin

Winter 2007-2008 Edition:
Chronic Pain
Cartilage Explained
Osteoarthritis Pain Relief

In the Winter 2007-2008 edition of The Arthritis Bulletin, editor Joan M. Bathon brings you the latest information on chronic pain associated with arthritis, in particular, osteoarthritis.

In this information-packed issue, you'll start with the Doctor's Letter. You'll get the latest news on chronic pain, and effective arthritis pain relief direct from America's #1 Best Hospital and Rheumatology Center.

In your first In-Depth report, Cartilage Explained you'll learn about cartilage, and the newest, most cutting-edge ways of dealing with cartilage damage brought about by injury and by aging.

Author Lynne C. Jones, Ph.D., is an Associate Professor at The Johns Hopkins University School of Medicine, where she is Director of the Center for Osteonecrosis Research and Education and Technical Director of the Arthritis Surgery Bone Bank.

When you order your copy of the Winter 2007-08 Arthritis Bulletin issue, in Cartilage Explained, you'll learn:

• What is cartilage?
• What is cartilage composed of?
• What types of cartilage are found in the knee?
• Are there any other types of cartilage?
• What can people do to protect their cartilage?
• Is aging inevitably associated with cartilage degeneration?
• How does trauma/injury damage cartilage?
• When should people seek medical attention for suspected cartilage injuries or osteoarthritis (OA)?
• How are cartilage injuries diagnosed in the knee?
• Can exercise alone help patients with damaged cartilage in the knee?
• What other non-invasive or minimally invasive treatments are available for treating the pain caused by damaged cartilage?
• How effective are such minimally invasive treatments?
• Are glucosamine and chondroitin supplements of any value for people with joint pain?
• What are some of the simpler surgical procedures for repairing damaged cartilage?
• What types of graft and implantation surgeries can be used to repair damaged cartilage?
• What are some of the most exciting, new directions in cartilage-repair research?
• What other experimental treatments are under investigation for cartilage preservation?
• Can the types of surgeries you've discussed—including the experimental ones—be used to treat rheumatoid arthritis?
• Will joint-replacement surgery continue to be the gold standard for patients with osteoarthritis?

You'll also get detailed descriptions of:

• mosaicplasty, or osteochondral autograft transplantation surgery (OATS)
• osteochondral allograft transfer system
• autologous chondrocyte implantation
• and how they compare with one another

plus, you'll receive:

• exercise guidelines
• illustrations of cartilage
• how osteoarthritis causes joints to degenerate-an illustrated guide

...and much more.

In the second In-Depth Report, Osteoarthritis Pain Relief author Clifton O. Bingham III, M.D., provides you with the most effective pain relief strategies if you suffer from osteoarthritis.

Clifton O. Bingham III, M.D., is an Assistant Professor of Medicine in the Divisions of Rheumatology and Clinical Immunology at The Johns Hopkins University. He is Director of the Johns Hopkins Rheumatology Clinics, a member of the Arthritis Center faculty, and Director of the Johns Hopkins Arthritis website.

Dr. Bingham's main research interest is the mechanisms of inflammation and joint destruction in arthritis. During the past five years, he has participated in more than 35 Phase I-IV clinical trials in OA and RA. His research has been published in peer-reviewed journals such as The New England Journal of Medicine, Rheumatology, and Arthritis Care and Research. He is a prior recipient of an Arthritis Investigator Award from the Arthritis Foundation.

As Dr. Bingham discusses in Osteoarthritis Pain Relief, you have more options for relieving osteoarthritis pain than ever before. Osteoarthritis Pain Relief starts with a thorough overview of the arthritis pain relief strategies currently available for osteoarthritis, and how effective they are. You will also get the latest news on the most promising emerging treatments for effective arthritis pain relief.

In your copy of Osteoarthritis Pain Relief, you'll learn:

• Which pain medication has the best risk-to-benefit ratio? And at what dosage?
• What are the risks and benefits of switching to traditional NSAIDs?
• Has the loss of COX-2 inhibitors such as Bextra and Vioxx—and the FDA's recent refusal to approve others such as etoricoxib (Arcoxia) and lumiracoxib (Prexige)—caused problems for you and other rheumatologists?
• Do you prescribe Celebrex—the only remaining COX-2 inhibitor in the U.S. market—for your patients?
• How do you address patient concerns that a COX-2 inhibitor may increase the risk of heart attacks and strokes?
• What do you make of the controversy between rheumatologists and the American Heart Association, which has issued osteoarthritis treatment recommendations, such as the administration of high-dose aspirin as the first-line therapy for osteoarthritis pain?
• If NSAIDs—either traditional ones or COX-2 inhibitors—are ineffective, are opioids the next logical step?
• Are intra-articular injections a good option for people with OA who have not responded to other treatments?
• Do topical analgesics such as counterirritants, salicylates, and capsaicin reduce osteoarthritis pain?
• Are glucosamine and chondroitin supplements of any value in treating osteoarthritis pain?
• What are your thoughts on over-the-counter osteoarthritis formulations?
• Do some osteoporosis drugs have potential as disease-modifying drugs for osteoarthritis?
• Are there new classes of drugs beyond COX-2 inhibitors that are being investigated for osteoarthritis pain?
• What's needed for osteoarthritis research to advance to the next level?

Plus, you'll also receive:

• exercise guidelines
• how osteoarthritis causes joints to degenerate—an illustrated guide
• drug charts comparing the latest medications for osteoarthritis pain relief

...and much more.

All this information is available to you right now as an instant PDF digital download for the special discounted price of 40% off, 49.95 only $29.95(US), [$29.95 (CDN)].

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Those who already subscribe to The Johns Hopkins Arthritis Bulletin will have already received this issue (Winter 2007-08), but countless more visitors to this website missed out on this crucial health information once all the printed issues sold out.

Due to the overwhelming demand for Cartilage/Osteoarthritis Pain Relief issue, thanks to this special offer, you can now get the instant PDF digital download edition at a 40% discount.

You'll get 48 pages of this invaluable arthritis information direct from Hopkins' expert panel of specialists at Johns Hopkins, ranked America's #1 Best Hospital for 19 consecutive years.

Just look at all you'll get in Cartilage/Osteoarthritis Pain Relief issue:

TABLE OF CONTENTS

Doctor Bathon's Letter:

• Chronic Pain
• Breaking the Circle of Pain
• Safe Use Of NSAIDS

In-Depth Report: Cartilage Explained

In-Depth Report: Osteoarthritis Pain Relief

Grand Rounds:

• Is the life expectancy of someone with rheumatoid arthritis (RA) reduced? If so, why?
• Methotrexate, RA, and fertility
• Lowering Prednisone Dosage Safely
• Ankylosing Spondylitis (AS) and TNF Therapy?
• Spinal Osteophytosis
• Genes and Arthritis

In no other Arthritis Bulletin issue will you find such detailed information on the topics of chronic pain, cartilage, and osteoarthritis pain relief.

SAVE 40%

This wealth of information is available to your right now as an instant digital download at 40% off the list price.

Normally, a subscription to the quarterly Johns Hopkins Arthritis Bulletin is priced at $199 per year for 4 issues, sent out in the post via Priority Mail. That's $49.95 per issue.

But for a limited time only, you can get this digital PDF download edition of Cartilage/Osteoarthritis Pain Relief from The Johns Hopkins Arthritis Bulletin for $49.95 only $29.95.

All of the Johns Hopkins publications are designed with YOU in mind, the busy person looking for the most comprehensive answers to your many questions about arthritis, from the world's leading experts.

Cartilage/Osteoarthritis Pain Relief provides 48 pages of detailed information direct from the doctors and researchers on the front line in the battle against arthritis.

Once you download Cartilage/Osteoarthritis Pain Relief, you can start reading it immediately. You'll be able to discuss what you learn with your doctor and loved ones, and apply all you learn at once, to help you make the most informed decisions about your health.

Cartilage/Osteoarthritis Pain Relief will help you take control of your health, secure in the knowledge that your information is coming from the most trusted name in the world in successful arthritis treatment.

And as always, your purchase is completely RISK-FREE. ISSUE comes with a full 100% money-back guarantee. If you're not satsified with Cartilage/Osteoarthritis Pain Relief issue, simply contact us within 30 days for a full refund.

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