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Johns Hopkins Health Alert

Ask the Doctor About Your Prescriptions

Johns Hopkins Health Alerts | Prescription Drugs | Drug Expiration Dates

Prescription Medication Question 1 -- Are medications that have passed their expiration dates good to use, or should they be discarded?

Think of expiration dates -- which the U.S. Food and Drug Administration (FDA) requires be placed on most prescription and over-the-counter medications -- as a very conservative guide to longevity. The expiration date is a guarantee from the manufacturer that a medication will remain chemically stable—and thus maintain its full potency and safety -- prior to that date. Most medications, though, retain their potency well beyond the expiration date, and outdated medications, whether prescription or over-the-counter, are not usually harmful.

In a study conducted by the FDA on a large stockpile of medications purchased by the military, 90% of more than 100 medications were safe and effective to use years after the expiration date. More recently, the FDA approved two-year extensions on expiration dates for a number of drugs, including the antibiotics Cipro (ciprofloxacin), penicillin, and tetracycline; the Tagamet (antiulcer/antireflux drug cimetidine); and Valium (diazepam), a tranquilizer. The drugs in the FDA study, however, were stored under ideal conditions -- not in a bathroom medication cabinet, where heat and humidity can cause drugs to degrade.

If your medications have been stored under good conditions, they should retain all or much of their potency for at least one to two years following their expiration date, even after the container is opened. But you should discard any pills that have become discolored, turned powdery, or smell strong; any liquids that appear cloudy or filmy; or any tubes of cream that are hardened or cracked. To help maintain potency, store your medications in a closet or cabinet located in a cool, dry room. Also, don’t mix medications in one container: chemicals from different medications can interact to interfere with potency or cause harmful side effects. If two or more medications have been mingled for any period of time, discard them. A few medications, like insulin and some liquid antibiotics, do degrade quickly and should be used by the expiration date. Also, consider replacing any outdated medications that you’re taking for a serious health problem, since its potency is more critical than that of an over-the-counter drug you take for a headache or hay fever. If in doubt, consult a pharmacist.

Prescription Drug Question 2 – Where’s the best place to store your medications?

It’s not the medicine cabinet in your bathroom. The heat and humidity from showers and baths can cause medications to break down, lose potency, and, in rare cases, even become toxic. To keep your medications in the best condition, keep them in a dry area away from heat and light, such as a dresser drawer. Kitchen cabinets are also a good choice, as long as they aren’t next to the stove, sink, or dishwasher. Wherever you keep your medications, make sure that bottles are tightly sealed after use.

Johns Hopkins Health Alerts | Prescription Drugs | Drug Expiration Dates

Posted in Prescription Drugs on March 6, 2007
Reviewed March 2010

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Health Alerts registered users may post comments and share experiences here at their own discretion. We regret that questions on individual health concerns to the Johns Hopkins editors cannot be answered in this space.

The views expressed here do not constitute medical advice, and do not represent the position of Johns Hopkins Medicine or MediZine LLC, which has no responsibility for any comments posted on this site.


I keep my prescription and over the counter drugs in my refrigerator in a plastic bag. I'd like to know opinions on this.

Posted by: makern | March 11, 2007



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