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Johns Hopkins Health Alert

The Risks of Long-Term Oral Steroid Use

Johns Hopkins Health Alerts | Lung Disorders | Risks of Long-Term Oral Steroid Use

The higher the steroid dose, the more likely that side effects -- cataracts, osteoporosis, diabetes, high blood pressure, muscle weakness, hair loss -- may occur.

As a growing number of people with lung disease are living longer, more people are taking long-term oral steroids for asthma, chronic obstructive pulmonary disease (COPD), and other chronic lung conditions.

Long-term use of oral steroids can cause serious side effects, ranging from osteoporosis to cataracts to high blood pressure and diabetes. If you’re taking an oral steroid, it’s critical to talk with your doctor about how to minimize these steroid side effects.

Corticosteroids can prevent or reverse inflammation in the airways, making them less sensitive to triggers. If you have severe asthma and you have tried high doses of inhaled steroids without success, your doctor may recommend oral steroids. Some people take oral steroids because they have COPD that other medications can’t relieve.

If you take daily oral steroids for months or years, particularly in moderate to high doses, you are at increased risk for developing any of a variety of side effects: cataracts, osteoporosis, diabetes, high blood pressure, muscle weakness, easily bruised skin, hair loss, facial hair growth in women, weight gain, and puffy cheeks. Other possible side effects include hyperexcitability, insomnia, and (in a small number of patients) aggressive behavior or even psychosis.

Steps you can take to avoid osteoporosis and other side effects:

  • Ask your doctor about getting regular bone scans to detect osteoporosis.
  • Get about 1,500 mg of calcium daily through nutrition or supplements. Because vitamin D helps the body absorb calcium, it may help to take 800 international units (IU) daily of vitamin D.
  • If you are diagnosed with osteoporosis, your doctor will recommend medication.
  • If you take moderate to high doses of corticosteroids, have regular eye exams to check for glaucoma.
  • Ask your doctor whether you can reduce your oral steroid dose by adding other medications.
  • Have your blood pressure checked regularly.
  • Also have your blood sugar checked frequently. Use of high dose steroids has been associated with the development diabetes.

Johns Hopkins Health Alerts | Lung Disorders | Risks of Long-Term Oral Steroid Use

Posted in Lung Disorders on December 6, 2007
Reviewed July 2009

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