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Johns Hopkins Health Alert

Screening Tests After Age 50

In this excerpt from a recent Health After 50 newsletter article, Johns Hopkins explains the difference between screening and diagnostic tests and provides a handy list of screening tests recommended for adults aged 50 and older.

A screening test looks for signs of an illness before symptoms develop. A diagnostic test provides information about a known problem or looks for disease after an illness is suspected.

For example, a blood test for prostate specific antigen (PSA) may be used to screen men for prostate cancer. But if PSA is elevated, a biopsy (a diagnostic test) is needed. Similarly, mammography is used to screen women for breast cancer, but a biopsy is needed to evaluate suspicious findings. In some instances, the same tests are used for both purposes, as when mammography is ordered to evaluate a suspicious breast lump. Some tests, such as PSA, may also be used to monitor response to treatment.

Here is a listing of recommended screening tests for women and men after age 50:

Screening Tests For Women:

  • Pap test (cervical cancer) -- Every three years if results are negative for three consecutive years; annually if you smoke or have multiple sex partners.
  • Human papillomavirus (HPV) test (cervical cancer) -- May be done along with a Pap test; not enough evidence to recommend routine screening.
  • Mammography (breast cancer) -- Annually for all women 50 and over.
  • Thyroid-stimulating hormone (TSH) test (thyroid disease) -- The United States Preventive Services Task Force doesn't recommend screening asymptomatic women, but other groups do. Talk to your doctor.
  • Dual-energy x-ray absorptiometry bone density test (osteoporosis) -- Once every two years beginning at age 65. Women with risk factors, as determined by their primary care providers, should begin at age 60.

Screening Tests For Men:
  • Prostate specific antigen test and digital rectal exam (prostate cancer) -- Black men and men with a family history of prostate cancer should begin annual screening at age 40. Others should begin at age 50.
  • Abdominal ultrasound (abdominal aortic aneurysm) -- Once only for men 65–75 who've ever smoked.

Screening Tests For Everyone:
  • Blood pressure check (cardiovascular disease) -- Once every two years; more frequently for people over 60 or with readings over 120/80 mm Hg.
  • Cholesterol and triglyceride levels check (cardiovascular disease) -- Once every five years; more frequently for people with a family history of heart disease.
  • Colonoscopy (colon cancer) -- Once every 10 years beginning at age 50; more frequently for those at high risk.
  • Fecal occult blood test (colon cancer) -- Annually, although its unreliability leads many organizations, including Johns Hopkins, to question its usefulness.
  • Fasting blood glucose test (diabetes) -- Every two to three years; more often if you're at high risk.
  • Sexually transmitted disease screening test -- At least once a year if you have multiple partners.
  • Glaucoma screening test -- Every three to five years; more often for people with diabetes or family history of glaucoma.
  • Dental cleaning and exam -- Every six months.

Posted in Healthy Living on October 15, 2008
Reviewed July 2009

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Health Alerts registered users may post comments and share experiences here at their own discretion. We regret that questions on individual health concerns to the Johns Hopkins editors cannot be answered in this space.

The views expressed here do not constitute medical advice, and do not represent the position of Johns Hopkins Medicine or MediZine LLC, which has no responsibility for any comments posted on this site.


I have been diagonsted with Congestive heart failure I have sever swelling in left leg. Some Doctors say the edema is from that others say its because of 27 lymph nodes that I had removed in 1989 when I had cervical cancer. What tests do I need to have to fine out whats causing the edema? Please Help

Posted by: sister_az.valleygirl | October 15, 2008

With the increased incidence of skin cancers, a full-body exam by a dermatologist should also be on the list of periodic screenings. Starting at what age, and how frequently?

Posted by: Pyles | October 18, 2008



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