I have also seen reports (though I have not read any original papers) that the reduction of stomach acid resulting from long-term use of GERD-reducing medications can hinder dissolution and adsorption of calcium, especially that taken in supplement form.

Additionally, some researchers have urged long-term users of such medications to make sure they have received the pneumonia vaccine, given the potential for reduced protection against pathogens in the stomach.

Having both serious GERD and a parent whose death was likely related to GERD, I am taking omeprazole daily and remain concerned about potential side effects.

As the doctor states:

"But as with any drugs, their beneficial effects are often offset by some negative consequences."

He is giving examples of the gastrointestinal side effects. A new study was just released Friday on the links between common treatments for indigestion, and low bone density, but since this alert came out on Labor Day, I am sure it was in line for publication on the holiday prior to that set of study results being released.

Clearly all patients should be aware of the potential side effects of every pill they take, from prescription, to over the counter medications, to vitamin pills. And particularly in view of their own health history.

If you have not already created a family health history, you can do so on line at https://familyhistory.hhs.gov/

If you don't want to enter any personal information into the computer, then download the sample PDF to have a look at the kinds of information you might like to include.

One should also keep a list of all medications and vitamins and supplements they take, and keep the list updated, so you can work with your doctor proactively.

I have suffered from GERD for about 6-7 years and it complicates/relates to my diagnoses of Asthma, chronic bronchitis and emphysema. I have been on protonix for about the same time. I was diagnosed with osteoporosis 2.5 years ago (though through meds and exercise, my bone density improved). I am concerned about getting osteoporosis again if my health fails and I can no longer do the exercise regime I now do. I read the research relating proton pump inhibitors with osteoporosis and am concerned about how to treat my GERD and not impair my calcium absorption (presumably due to lack of stomach acid).

Are there other options besides proton pump inhibitors and H2 blockers (which were tried but not successful before my placement on protonix)?

I assure you this medication is harmful over the long term. I have been takig Prilosec for about 5 yrs and decided to come off it after developing the same kind of pain experienced before I started taking it. I also had this great sense of fullness occasionally that was very uncomfortable. I Googled this subject and was surprised at how many people have the same side effects. I am now taking DGL before I eat, aloe juice twice a day. I started keeping a food diary of what foods do and do not cause indigestion. As you can probably guess the main culprit is processed foods, so I am now making most of my own meals, or sticking to a protein and vegetable combo and not mixing in carbs. I will have carbs with vegetables, but no protein. So far it is working and what a great relief. Still have to take Pepcid every few days, as I have only been on this program for a month. Believe me, if I can get to the point where this can be controlled with diet and natural supplements I will NEVER take this type medication again.