If you have diabetes, you know how important it is to control your blood glucose and keep it within normal range. But sometimes, depression can get in the way. Now a study in Diabetes Care links the antidepressant Wellbutrin XL with improved control.
Individuals with diabetes who are depressed may benefit from the antidepressant bupropion (Wellbutrin XL), which can lift their spirits and improve blood glucose control, according to an article in Diabetes Care (Volume 30, page 4590).
While similar results have been reported before, lower glucose levels were thought to result from the weight loss and improved self-care that often accompany successful depression treatment. But researchers are now finding that a better mood alone may lead to improved glycemic control over the long haul.
In a two-phase, open-label trial, 93 participants with type 2 diabetes and major depression took Wellbutrin XL, an antidepressant associated with weight loss, for just over two months. Of the 75 volunteers who stayed on Wellbutrin XL for 10 weeks, 84% reported improved mood, weight loss, and better self-care with diet and exercise. At the same time, the participants experienced a 0.5% reduction in HbA1c levels.
Looking at whether these improvements would last if they took the medication longer, a positive mood was most important for keeping glucose under control for another six months, regardless of weight loss or self-care changes.
While the exact mechanisms behind better glycemic control need further study, treating any accompanying depression is clearly important for managing diabetes.
