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Johns Hopkins Health Alert

The Link Between Vitamin D Deficiency and Late-Life Depression

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Low levels of vitamin D are common in older adults, often causing high levels of parathyroid hormone (hyperparathyroidism) -- and both may be associated with depression in older adults, according to a study in the Archives of General Psychiatry (Volume 65, page 508).

Researchers in the Netherlands measured blood levels of vitamin D and parathyroid hormone in 1,282 residents ages 65 to 95 and assessed any symptoms of depression. Twenty-six participants had major depression and 169 had minor depression.

Researchers found that overall, 39% of men and 57% of women had insufficient levels of vitamin D. These levels were 14% lower in participants with either major or minor depression than in those without depression. In addition, parathyroid hormone levels were 5% higher in people with minor depression and 33% higher in those with major depression than in those who were not depressed.

It is unclear whether vitamin D deficiency and the resulting hyperparathyroidism come before or after depression, but people may see an improvement in symptoms of depression after treating low vitamin D levels. Ask your doctor for a blood test to assess your levels; if need be, add a supplement to your daily diet or just head outside for 15 minutes each day -- sun exposure is the most effective way to absorb vitamin D.

Posted in Depression and Anxiety on August 31, 2010
Reviewed January 2011


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